This is an example of a Jmol presentation (click on the "About" menu above for more info on Jmol).
Some test stuff.
Color protein
using a link.
Test of a simple button. Make pretty.
Test of a toggle button. Color protein yellow
Presentation by Craig T. Martin, Department of Chemistry, University of Massachusetts. September 12, 2004.
Use the menu above to access its features.
About - provides information about this presentation, about Jmol and Jmol.js, and about JmolShell
Cmd - provides a larger command line for executing Jmol commands.
Help - provides help
Reset - Redraws the molecule to its starting view and rendering
ABSTRACT:
Regulatory factor X (RFX) proteins are transcriptional activators that recognize X-boxes (DNA of the sequence 5'-GTNRCC(0-3N)RGYAAC-3', where N is any nucleotide, R is a purine and Y is a pyrimidine) using a highly conserved 76-residue DNA-binding domain (DBD). DNA-binding defects in the protein RFX5 cause bare lymphocyte syndrome or major histocompatibility antigen class II deficiency. RFX1, -2 and -3 regulate expression of other medically important gene products (for example, interleukin-5 receptor alpha chain, IL-5R alpha). Fusions of the ligand-binding domain of the oestrogen receptor with the DBD of RFX4 occur in some human breast tumours. Here we present a 1.5 A-resolution structure of two copies of the DBD of human RFX1 (hRFX1) binding cooperatively to a symmetrical X-box. hRFX1 is an unusual member of the winged-helix subfamily of helix-turn-helix proteins because it uses a beta-hairpin (or wing) to recognize DNA instead of the recognition helix typical of helix-turn-helix proteins. A new model for interactions between linker histones and DNA is proposed.