Welcome to the Gross Lab

Department of Biochemistry and Molecular Biology
Program in Molecular and Cellular Biology
University of Massachusetts-Amherst
Amherst, MA 01003


EGF molecule

Click for a larger image (500 kB).

[Research Interests] [Present Members] [Past Members] [Some Links]

What are our research interests?

Research in the Gross lab focuses on receptor-mediated signaling in individual cells and cell populations. The epidermal growth factor receptor (EGFR) is our main interest. Quantitative CCD imaging technology allows us to measure EGF binding, [Ca2+] signaling, fluorescent EGF processing, and GFP-EGFR trafficking, all in individual cells. We are particularly interested in the molecular specific interactions between the EGFR and intracellular structural elements. We are also actively working on the mode of EGF signal transduction in mammalian cumulus cells. (Cumulus cells surround the oocyte in the ovarian follicle.)

About the background

Shown in the background is the NMR solution structure of our second-favorite molecule, epidermal growth factor. The image was rendered using RasMol, a freeware molecular visualization program available at the RasMol Home Page here at UMass. EGF is spinning at the top of the page.

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Meet our present lab members


Dave Dr. David J. Gross Zhong Zhong Zhao
Damien Damien Garbett Kate Kate Beebe

Lab trip to
Tanglewood

Lab Trip to Tanglewood to see the Boston Symphony Orchestra
Back: Mike, John and Jeff. Front: Jun, Mieu, Dave and Julia.

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Some of our past lab members

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Here are some fun and useful links:

At UMass

Other Places

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Comments? Write: dgross@biochem.umass.edu

last update 10 August 2001