(See Below: 1. Presentation Schedule, 2. Paper Suggestions, 3. Resources/Announcements)
(i) Attend (>90%)
(ii) Participate (e.g. ask questions, volunteer information)
(iii) Present/co-present (once, maybe more)
Date |
Presenters |
Paper(s) |
Sign. Trans. |
Mem. Domains |
Prot. Lipid. |
|---|---|---|---|---|---|
9/14 |
Max & Steve |
Karginov et al. (2010) Engineered allosteric activation of kinases in living cells. Nature Biotechnology 28:743. Supplementary materials: methods, Suppl figs, mov2, mov3, mov4 |
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9/21* |
Timo & Ben |
Xu et al. (2011) A human IgM signals axon outgrowth: coupling lipid raft to microtubule. J Neurochem 1-13. doi: 10.1111/j.1471-4159.2011.07416.x Suppl. Inf.: Xu_Supp_Fig_Leg.pdf, Xu_FigS1.pdf, Xu_FigS2.pdf, Xu_FigS3.pdf *Professor Holden will moderate the presentation & discussion. (RMW out of town) |
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9/28 |
Rui, Dave & Chandra |
Rossman et al. (2010) Influenza virus M2 protein mediates ESCT-independent membrane scission. Cell 142:902-193. Suppl. Inf.: Movie_legends.pdf, movie1.mp4, movie2.mp4, movie3.mp4, movie4.mp4. 'Leading edge' commentary by Göttlinger. |
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10/05 |
Ann-Joy & Jing |
Sundaresan et al. (2011) The deacetylase SIRT1 promotes membrane localization and activation of Akt and PDK1 during tumorigenesis and cardiac hypertrophy. Science Signalling 4 (182), ra46:1-12. Suppl. Inf.: Sundaresan_SI.pdf |
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10/12 |
Michelle & Hanwei |
Zhang et al. (2011) Carboxyl-group footprinting maps the dimerization interface and phosphorylation-induced conformational changes of a membrane-associated tyrosine kinase. Mol Cell Prot 10.6 Suppl. Inf.: Zhang_SI.pdf |
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10/19 |
Feng & Kratae |
Miller et al. (2010) Aquaporin-3 mediates hydrogen peroxide uptake Suppl. Inf.: Miller_SI.pdf |
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10/26 |
Xian & Yi-Cheun
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Weise et al. (2011) Membrane-Mediated Induction and Sorting of K-Ras Microdomain Signaling Platforms. J Amer Chem Soc 133:880-887. Suppl. Inf.: Weise_SI.pdf |
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11/02 |
Xuni & Ying |
Gureasko et al. (2010) Role of the histone domain in the autoinhibition and activation of the Ras activator Son of Sevenless. Proc Natl Acad Sci USA 107:3430–3435. |
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11/09 |
Muslum & Gokhan |
Tognon et al. (2011) A tripartite complex composed of ETV6-NTRK3, IRS1 and IGF1R is required for ETV6-NTRK3-mediated membrane localization and transformation. Oncogene. Advance online publication, August 1; doi:10.1038/onc.2011.323
Suppl. Inf.: Tognon_SI.pdf |
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11/30 |
Luis & Heidi |
Mi et al. (2011) Simultaneous visualization of the extracellular and cytoplasmic domains of the epidermal growth factor receptor. Nat Struct Mol Biol 18:984-989. Suppl. Inf.: Mi_SI.pdf |
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12/07 |
Muneer & Fabian |
Jaqaman et al. (2011) Cytoskeletal Control of CD36 Diffusion Promotes Its Receptor and Signaling Function. Cell 146:593-606. Suppl. Inf.: Jaqaman_TS1.pdf, Jaqaman_M1.avi, Jaqaman_M2.avi, Jaqaman_M3.avi, Jaqaman_M4.avi, Jaqaman_SI_Legends.pdf 'Leading edge' commentary by Zimmberg&Hess.pdf |
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Paper |
Sign. Trans. |
Mem. Domains |
Prot. Lipid. |
|---|---|---|---|
Loose et al. (2011) Min protein patterns emerge from rapid rebinding and membrane interaction of MinE. Nat Struct Mol Biol 18:577-583. Suppl. Inf.: MinE_S1.pdf, MinE_S2.mov, MinE_S3.mov, MinE_S4.mov, MinE_S5.mov, MinE_S6.mov |
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| Resource | Comment |
| Hanahan & Weinberg (2000) The hallmarks of cancer. Cell. 100:57–70, and Hanahan & Weinberg (2011) Hallmarks of cancer: the next generation. Cell. 144:646–674. | Robert Weinberg, MIT, will visit UMass Oct. 18 & give a seminar in the MCB program. These two co-authored review articles may serve as a primer for his talk. |
| http://stke.sciencemag.org/ | The Signal Transduction Knowledge Environment, a website hosted by Science magazine. |
| "The UCSD Signaling Gateway is a comprehensive and up-to-the-minute resource for anyone interested in signal transduction." | |
| Honerkamp-Smith et al. (2009) An introduction to critical points for biophysicists; observations of compositional heterogeneity in lipid membranes. Biochim Biophys Acta 1788:53-63. | A tutorial on the thermodynamics of liquid-liquid phase separation in model biological membranes (GUVs). Serious students of cell membranes should read this. |
| Baumgart et al.(2007) Large-scale fluid/fluid phase separation of proteins and lipids in giant plasma membrane vesicles. Proc Natl Acad Sci USA 104:3165–3170. | This paper provides evidence that the lipids in cell membranes are able to produce liquid-liquid phase separation. |
| Groves & Kuriyan (2010) Molecular mechanisms in signal transduction at the membrane. Nat Struct Mol Biol 17:659-665. | A relatively recent review that includes cell interactions with micropatterned membrane surfaces. |
Gureasko et al. (2008) Membrane-dependent signal integration by the Ras activator Son of sevenless. Nat Struct Mol Biol 15:452-461. Suppl. Inf: Gureasko_SI.pdf News & Views on Gureasko et al. by Tony Pawson: Findlay&Pawson (2008) |
Collaborative effort by the Groves and Kuriyan labs to that demonstrates the necessity of the membrane surface to generate effective catalytic activity in the Ras/Sos system. |
| Martin et al. (2011) Post-translational myristoylation: Fat matters in cellular life and death. Biochemie 19:18-31. | Reviews how protein lipidation of caspase substrates generates membrane-associated proteins, and their possible involvement in apoptosis. |