Structural biology of membrane proteins is a major focus of our research. Membrane proteins represent up to 30% of various genomes and 60% of drug targets, and play critical roles in bioenergetics and in the transport of material and information between cells. Despite their fundamental and biomedical importance, structural biology of membrane proteins lags far behind that of soluble proteins. It is clear that understanding structure and function in these challenging complexes will continue to require integration of a variety of techniques to address the questions and systems of interest. Our laboratory takes such an approach, integrating the emerging tools of solid-state NMR with a variety of other biophysical, biochemical, and molecular biology approaches to address structure and function in important membrane proteins.