Potassium Channel from Streptomyces Lividansat 3.2 Angstrom Resolution
D.A. Doyle, J.M. Cabral, R.A. Pfuetzner, A. Kuo, J.M. Gulbis, S.L. Cohen, B.T. Chait, R. Mackinnon "The Structure of the Potassium Channel: Molecular Basis of K+ Conduction and Selectivity" Science (1998) 280, 69-77.
(PDB entry 1BL8.PDB)
Introduction
Cartoon of the K+ channel structure Turn off rotation Reset view The potassium channel is perhaps best known for it's role in electrical signalling in neurous system. However these integral membrane proteins are found in nearly all living organisms and take part in numerous biological processes. These channels allow a very high permiability for K+, Rb+, and Cs+ across the cell membrane while exhibiting immeasurably low permiablility of the smaller alkili metals Na+, and Li+. In the paper above, the x-ray crystal structure of the potassium channel from Streptomyces Lividans is reported to 3.2 Angstrom resolution. The intent of this presentation is to provide an overveiw of key features in the proteins structure and function. Use the menu above to access features of this presentation. Story - will walk you through specific aspects of the structure. Features and Controls - allow you control elements of the structure as you like. Presentation by Jesse T. Charette, Department of Chemistry, University of Massachusetts Amherst. May 6, 1999.
The potassium channel is perhaps best known for it's role in electrical signalling in neurous system. However these integral membrane proteins are found in nearly all living organisms and take part in numerous biological processes.
These channels allow a very high permiability for K+, Rb+, and Cs+ across the cell membrane while exhibiting immeasurably low permiablility of the smaller alkili metals Na+, and Li+.
In the paper above, the x-ray crystal structure of the potassium channel from Streptomyces Lividans is reported to 3.2 Angstrom resolution. The intent of this presentation is to provide an overveiw of key features in the proteins structure and function.
Use the menu above to access features of this presentation.
Story - will walk you through specific aspects of the structure.
Features and Controls - allow you control elements of the structure as you like.
Presentation by Jesse T. Charette, Department of Chemistry, University of Massachusetts Amherst. May 6, 1999.