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Apply

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()

Highlight key N-terminal domain features

See the , in space filling mode (stripping away protein residues 350-398, 632, 652-658, 659-663).

Focus on

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Nontmpl
Template
Nontmpl
Template
Nontmpl
Template
RNA
Nontmpl
Template
Nontmpl
Template
Nontmpl
Template

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In the transition from initiation to elongation, one part of the structure maintains contact between the N and C terminal domains.

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Load

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Karsten idea

He suggests that the base (or just past the base) of the specificity loop interacts with the template strand. Zoom in on the

on specif-loop : template strand

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1ARO
1CEZ
2pi5
2pi4
1QLN
3e2e
3e3j
1msw
1h38
1s0v
1s76
1s77

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>

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	-17t	P
	-16n	N3 A
	-13n	P
	-12n	O4Õ
	-12n	P
	-12n	P
	-11n	P
	-11n	base
	-8t
	-8t or -7t	base
	-7t or -6t	base
	-7t or -9t or -10t	P / base / base
	-6t or -7t	Sugars
	-6t	P
	-5t	Base HPhobic
	-5t	Base
	-5t	P
	-4t or -6t	Sugar / P
	-4t	N2
	-4t	O4Õ
	+2r	2Õ OH
	+2n or +3n
	+2n	stacking
	+3t	P
	+3r	2Õ OH
	+5t	P
	+5t	O4Õ
	+5r	P
	+5t	P
	+6t	3Õ OH
	+6t	P
	+6t	P
	+7r	Base
	+7r	2Õ OH
	+7n	P
	+7t	P
	+7n	base
	+7n or +6n	stacking
	+7r	3Õ OH
	+8t or +7n	stacking / minor
	+8n	P
	+13n	P

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