Tsr model coordinates courtesy of Sung-Hou Kim, UC Berkeley.


Lab News:

8/2018 Lab alumnus Amber (Yael) Balazs will give the keynote address at the UMass Chemistry Researchfest!

7/2018 Maryam Kashefi wins a Protein Science Travel Award to present her work at the Protein Society Meeting in Boston, MA. Nikita, Aruni, and Lynmarie attend the Receptorfest Meeting at Cornell.

6/2018 Lynmarie organizes the "Molecular Biophysics of Membranes" FASEB conference at St. Bonaventure University in Olean, NY. The talks are fabulous, plus lots of interesting discussions -- what a great community! Congrats to Maryam on her first conference talk.

6/2018 Welcome to Nikita Malik, our new postdoc. She joins us after completing her PhD doing NMR and other biophysical studies of a centromere protein with Ashutosh Kumar at IIT Bombay. Welcome also to William Farrell who joins us for summer research through the CURE REU program.

5/2018 Lynmarie enjoys hooding and celebrating our two PhD graduates this year: Libbie and Xuni!

4/2018 We welcome Aruni Karunanayake Mudiyanselage back to the lab as a Research Fellow. She worked with us previously in 2013 before working with the Martin and You labs.

2/2018 Lynmarie co-chairs and speaks at a symposium on transmembrane signaling at the Biophysical Society Meeting in San Francisco.

2/2018 A fond goodbye to Dr. Xuni Li and we wish her all the best as she starts her next chapter as Research Associate at the UMass Medical School Mass Spectrometry Facility.

1/2018 Xuni Li defends her thesis: Congratulations!!

1/2018 We welcome two undergraduates into the lab, Tiernan Kennedy and Gulalai Shah.

1/2018 Happy 10th Anniversary to Proteopedia!

12/2017 Kiki Carey is awarded a Commonwealth College Research Assistant Fellowship - congrats Kiki!

11/2017 Libbie defends her thesis: Congratulations Dr. Haglin!! Her gorgeous chemoreceptor array assembly is on the cover of Biochemistry this month too!

9/2017 Libbie's first paper is accepted for publication in Biochemistry!

8/2017 Maryam's first paper is accepted for publication in Journal of Physical Chemistry B!

7/2017 Xuni Li wins a Finn Wold and Protein Science Travel Award to present her work at the Protein Society Meeting in Montreal, Canada.

6/2017 Welcome to Kadejah Johnson, who joined the lab for the summer in the SPUR program.

5/2017 Libbie Haglin is one of 4 students selected to present a talk at the UMass CBI/BMB-UMassMed BMP retreat.

5/2017 Congratulations and a fond farewell to senior Karen Li who worked with us since her freshman year on an ABC transporter project: she was also one of ten students in her graduating class to be selected a 21st Century Leader!

5/2017 Congratulations to Kiki Carey who received the Undergraduate Award in Analytical Chemistry from ACS at the Chemistry awards dinner.

3/2017 Maryam Kashefi presents her work at the ENC (Experimental NMR Conference) in Asilomar, CA.

7/2016 Lynmarie co-organizes the FASEB meeting "Molecular Biophysics of Membranes" in Snowmass, Colorado

4/2016 Libbie Haglin is selected to give a talk at the Symposium on Biomolecular Structure, Dynamics, and Function at Brown University.

1/2016 Maryam Kashefi attends US-Canada Winter School on Biomolecular Solid-state NMR in Stowe, Vermont

10/2015 Libbie Haglin wins the Biophysical Society Award for Outstanding Student Poster at the "Biophysics of Proteins at Surfaces" meeting in Madrid, Spain.

6/2015 Cheyenne Hakes joins us from SUNY Cortland, for summer research with the CURE REU program.

6/2015 Alumni reunion honoring the memory of Bob Weis is a great success: wonderful tribute talks by Bob's alumni Anas Chalah and Tania Besschetnova, and a great turnout of lots of young alumni.

12/2014-1/2015 Installation of new NMR spectrometer!

11/2014 Local hydrogen exchange in chemoreceptor complexes paper published in Biochemistry. Congratulations Seena Koshy and Xuni Li.

11/2014 Yael Balazs (PhD 99, NMR Facility Director at Technion University) visits to give a seminar.

Fall 2014 Lynmarie enjoys reconnecting with lab alumni during seminar trips: Stacy Seeley (PhD 95, now Professor and Head of Chemistry and Biochemistry at Kettering University) and Julissa Gonzalez (summer research 2010, now a graduate student at University of Puerto Rico Rio Piedras).

8/2014 Libbie Haglin wins a William E. McEwen Fellowship Award for Outstanding Poster Presentation at this year's ResearchFest.

6/2014 Meaghan Molloy is featured on the UMass website.

5/2014 Karen Li receives a CURE fellowship for summer research at UMass

4/2014 Michael Harris accepts a position as Applications Engineer at Bruker Biospin.

4/2014 Meaghan Molloy receives a Summer Undergraduate Research Fellowship from the Frankel Cardiovascular Center University of Michigan Health Center

Welcome to the Thompson Lab

Structural biology of membrane proteins is a major focus of our research. Membrane proteins mediate key life processes: cells employ membrane proteins to harness energy, sense the environment, and import molecules. Understanding the mechanisms of these critical processes, as well as designing pharmaceuticals targeting membrane proteins to treat diseases, is limited by the challenging nature of membrane protein studies. Recent advances in membrane protein expression and structure determination make this an exciting time to work on membrane proteins and advance this frontier area in biology. Our laboratory combines a variety of tools including solid-state NMR and mass spectrometry with other biophysical, biochemical, and molecular biology approaches to address structure and function in important membrane proteins. We study bacterial chemotaxis receptors to understand mechanisms of transmembrane signaling and ABC transporters to understand mechanisms of transmembrane transport. Bacterial chemotaxis has many interesting potential applications, such as targeting chemotaxis proteins with novel antibiotics, and harnessing chemotaxis for sensing or to direct delivery of therapeutics.

Contact information:
Lynmarie Thompson LGRT 374, University of Massachusetts
710 North Pleasant St.
Amherst, MA 01003











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