Chem 728 - Physical Biochemistry
TTh 9:30-10:45, GSMN 51
Syllabus | Instructor | News | Objectives | Texts | Grading | Lec Notes 2000
Instructor: Craig T. Martin
Office hours by appointment.
Recent news:
- Thanks to Rebecca for pointing out an on-line NMR text.
- Final exams and grades are ready for pickup in LGRT 403D! Thanks for agreat semester!
- Answer keys are in for Exam III and for Exam IV.
- Here's a hint for the last problem of Exam III. The equations you need were presented in class (twice - once in the last lecture or two). But I've found that they are not EXPLICITELY in the text or my on-line notes. So here's a hint, for those still struggling.
- The final exam(s) have been handed out. Copies can be downloaded here:
- A short paper for discussion on Thursday is (finally) available for download.
- A package of Extend kinetics files is available for download for the Mac or the PC.
- A package of MathCAD files is available for download for the Mac or the PC.
- A simulation of exact vs "linearizable" ligand binding is available for download.
- The average score on Exam II was 87 (the average was 90 for Exam I). The answer key for Exam II is available for download.
- Answer key for Exam I is available for download.
- NMR Study Materials:
- Watch here for news updates, including an updating syllabus, and exam material, including answer keys.
- You may want to check out the course home page for last Fall's Chem 471, an introduction to physical chemistry. In particular, you might want to look at the lecture notes.
- For a quick review of particle in a box, look at the lecture notes for 471.
Course objectives
Biological molecules underlie all of life and represent chemistry far more complex than most chemists encounter. On the other hand, they of course follow all of nature's pinciples (chemistry), and so can be approached from that perspective. The principles of physical chemistry are the key to understanding both the behavior of these molecules (folding, binding, catalysis) and the techniques available for studying their structure and mechanism.
This course aims to convey how these principles are applied to biological systems. The course will emphasize problem solving, with the goal of understanding, not memorization. Computer resources will introduce us to tools for understanding structure, complex binding equilibria, and enzyme kinetics.
Texts
| Required
| van Holde, Johnson, & Cho, "Principles of Physical Biochemistry," 1998, Prentice Hall.
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| Chem 728 lecture notes
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| Supplemental
| Cantor & Schimmel, "Biophysical Chemistry," 1980(!), Volumes I-III, W. H. Freeman.
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| Sanders & Hunter, "http://www.oup-usa.org/search97cgi/s97_cgi?action=View&VdkVgwKey=%2E%2E%2F%2E%2E%2F%2E%2E%2F%2E%2E%2F%2E%2E%2Fdata%2Finfobox%2Fwww%2Fusa%2Fisbn%2F0198555679%2Ehtml&DocOffset=1&DocsFound=2&QueryZip=catalog+%3Ccontains%3E+general+and+description+%3 TARGTex>Modern NMR Spectroscopy," 1993, Oxford Univ Press.
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| Others: your favorite PChem texts, see library reserves for Chem 471-475
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The texts are on reserve in the Physical Sciences Library
Grading / Requirements
Exams are take-home, but MUST be worked on independently. Honesty is critical and violations will not be tolerated.
Problem sets can and should be worked on collaboratively
| 20%
| Problem Sets and Projects
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| 20%
| Exam I
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| 20%
| Exam II
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| 20%
| Exam III
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| 20%
| Exam IV
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Instructor | News | Objectives | Texts | Grading