Controlling charge transfer chemistry in nanoparticle/metalloenzyme hybrids

Protein/nanoparticle hybrids are at the frontiers of biomedicine and materials chemistry. We study how redox proteins and O2-utilizing enzymes function on nanoparticle surfaces, which will help to shape our understanding of protein dynamics as related to catalysis.


Highlights:

Adapted amide H/D exchange to map surface binding of nanoparticles on proteins

Reversible assembly of micron-sized protein:nanoparticle hybrids

Inhibited protein:protein recognition with nanoparticles

Catalyzed intermolecular electron-transfer on nanoparticle surfaces