Jianhan Chen Research Group
Computational Biophysics and Biomaterials

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December 30, 2010
Our paper titled "Intrinsic Disorder Mediates the Diverse Cell Cycle Regulatory Functions of the Cyclin-dependent Kinase Inhibitor, p21Cip1" was just accepted by Nature Chemical Biology! This is a joint work with the Kriwacki lab in St Jude Children's Research Hospital.

December 15, 2010
We discussed key challenges and recent advances in physics-based modeling of intrinsically disordered proteins in a review as part of the Special Issue "Advances in Molecular Recognition" of the International Journal of Molecular Sciences. (MDPI)

November 30, 2010
Our first paper on topology-based modeling of IDPs is accepted by PROTEINS. Congratulations, Debabani! (PROTEINS)

October 28, 2010
The group participated the Protein Folding and Dynamics Mini-Symposium as part of the 45th Midwest Regional ACS meeting in Wichita, KS. Jianhan and Jian presented works on coarse-grained modeling of IDPs and membrane proteins.

August 8, 2010
We welcome Dr. Timothy H. Click, who is joining the lab as a postdoctoral fellow from George Kaminski's lab at Worcester Polytechnic University. Tim received his Ph.D. in Chemistry from the University of Oklahoma in 2007.

August, 2010
We celebrated our newest and cutest member, Alice R. Chen, At birth, Alice weighted 3.26 kg and was 49.5 cm long.

July 11-16, 2010
Debabani attended the first GRC on Intrinsically Disordered Proteins in Davison College and presented her work on electrostatics in recognition of IDPs. The meeting obviously was a lot fun!

May 10, 2010
Jianhan received a Faculty Scholar Award from Kansas INBRE!

March 15, 2010
Our first paper on structural characterization of novel synthetic channel-forming peptides using a combination of NMR, biophysical characterization and computer modeling is finally accepted by PROTEINS.

March 10, 2010
We successfully renewed the R01 support from NIH NIGMS (PI: Tomich) on the collaborative project on novel synthetic channel-forming peptides with the Tomich Lab.

March 2, 2010
Our work on implicit solvent and intrinsically disordered proteins will be supported by a five-year CAREER award from NSF! (KSU News Release))

Feb 19-22, 2010
Debabani, Jianhan and Weihong attended the 54th Biophysical Society Annual Meeting in San Francisco, CA. Congratulations to Debabani for winning Travel Awards from the IDP subgroup and Johnson Cancer Center, respectively. Here is some photographic evidence of how Debabani and Weihong took advantage of the conference to absorb exciting new knowledge.

November 16, 2009
K-State Collegian published a news piece on our shared Beocat cluster.

November 7, 2009
The whole group attended the 2009 Kansas Physical Chemistry Symposium. Debabani and Jian presented their posters.

November 1, 2009
We thank the Terry C. Johnson Center for Basic Cancer Research for another generous Innovative Research Award. Also congratulations to Melissa for receiving a Cancer Research Award and to Debabani for receiving a postdoctoral travel award from the Cancer Center.

August 4-7, 2009
Jianhan participated as one of the Instructors in the 2009 MMTSB/CTBP Summer Workshop in San Diego. The workshop was attended by about 30 graduate and postdoctoral researchers. Jianhan lectured on CHARMM analysis, implicit solvent methodology, and replica exchange simulation technique.

July 14, 2009
We welcome Weihong Zhang to the lab. Weihong received his B.Sc. in Bioengineering from Beijing University of Chemical Technology and will be a first-year graduate student in the Biochemistry Graduate Program at K-State.

May 21-26, 2009
Jianhan attended the Wakonse Conference on College Teaching as a K-State Wakonse Fellow. A refreshing break from research! (KSU K-Statement News)

May 12, 2009
Debabani's paper on structural interpretation of PRE-derived distances was accepted by JMB. (PubMed)

April, 2009
We recently expanded our shared Beocat cluster to over 1000 computational cores! It is the largest in Kansas.

Feb 28-Mar 04, 2009
Ahlam, Debabanni and Jianhan presented at Biophysical Society 53rd Annual Meeting in Boston, MA.

Feb 18, 2009
Debabani's paper in simulation of the disordered states of KID was accepted by JACS. (PubMed)

Feb 5, 2009
After much delay, Dr. Jian Gao finally arrived to join us at KSU! Dr. Gao received his Ph.D. in Chemical Engineering in 2005 from Institute of Process Engineering (IPE), Chinese Academy of Sciences. Prior to joining the lab, Dr. Gao was an Assistant Professor in the State Key Laboratory of Multiphase Complex System at IPE. Dr. Gao will work on coarse-grained modeling of membrane peptides.

Jan 22, 2009
Our first paper on IDPs titled "Intrinsically Disordered p53 Extreme C-Terminus Binds to S100B(ββ) through “Fly-Casting”" is accepted as a Communication to JACS. (PubMed)


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