Jianhan Chen Research Group
Computational Biophysics and Biomaterials

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Dec 19, 2018
The group celebrated a highly successful year 2018 and holidays together! What a great year with so much to be thankful for and to celebrate together! To name a few, Zhiguang & Mahdieh's discovery of hydrophobic gating in BK channels, Azar's new faculty position in the beautiful La Jolla, addition of two bright new graduate students in Erik and Xiping, Xiping's new baby son, a newly minted PhD in Xiaorong, and several new federal grants to support various research projects, Jianhan surviving teaching Stat Mech and then Quantum Mechanics both the first time ever ... We wish everyone the best and look forward to another great year in 2019!

Dec 17, 2018
Our warmest congratulations to Xiaorong for a highly successful defense of her PhD dissertation on "Multi-scale simulations of Intrinsically Disordered Proteins"!

Dec 8, 2018
We are thrilled to add two new graduate students to the lab! Erik Nordquist hails from Idaho. He has a BS from the College of Idaho, majoring in Physics-Mathematics and Chemistry with minors in Computer Science, History, and Philosophy!!. Xiping grew up in the legendary Ji'An city of China. He has a BS in Chemistry from Nanchang University and a MS from Xiamen University, developing density functional valence bond methods. We look forward to many exciting contributions from Erik and Xiping in the coming years!

Nov 30, 2018
Congratulations to Mahdieh for winning another Best Poster Award, this times at 8th Life Sciences Graduate Student Symposium of UMass!

Oct 20, 2018
Xiping and Mahdieh presented their works on GPU accelerated implicit solvent and gating of BK channels in the 15th Annual North Eastern Structure Symposium. Congratulations to Mahdieh for wining the Best Poster Award!

Aug 28, 2018
Congratulations to Xiaorong Liu for being selected as one of the six speakers of the annual UMass Chemistry ResearchFest and winning the prestigious William E. McEwen Graduate Fellowship!

Aug 24, 2018
We thank NIGMS for a generous Administrative Supplements for Equipment of $140K for acquiring additional GPU computing nodes! It will significantly increase our computing capacity to work on several NIH supported projects!

Aug 22, 2018
Group members, Mahdieh, Xiaorong and Wayne, presented their exciting works at the ACS national meeting in Boston. The crowds were unusually large (not totally kidding)!

Aug 17, 2018
The group went to UMass Berkshire Dinning Common to enjoy the No. 1 Campus Food in the US and say farewell to Mara!

July 18, 2018
Congratulations to Zhiguang and Mahdieh for getting their paper on hydrophobic gating of BK channels accepted by Nature Communications! It is a lot of hard work and their exciting discovery will have great impacts on those who are interested in BK and other ion channels! (UMass News Release)

July 10, 2018
We received a 4-year grant from National Science Foundation (NSF) to develop efficient GPU-accelerated computational techniques and study how proteins may exploit highly flexible structures for function! (UMass News Release)

July 8, 2018
The group celebrated Kuohao's highly productive tenure in the Chen lab at Jianhan's house! Kuohao will move to University of Kentucky to be a Staff Scientist in the College of Pharmacy at the end of July. It was a bittersweet moment and we all wish Kuohao and his family the best!

July 1, 2018
The Journal of Molecular Biology Special Issue on "Intrinsically Disordered Proteins: Structure, Function and Therapeutics", co-edited by Jianhan Chen and Richard Kriwacki, is now available online. The editorial overview can be found here.

June 15, 2018
Our collaborative project with Ned Debold (Kinesiology) and DV (Chemistry) on development of a light-sensitive, high-energy molecule to power muscle function during acute myocardial ischemia and fatigue has been funded by a two-year Innovative Project Award by American Heart Association. (UMass News Release)

April 11, 2018
Congratulations to Katrina for winning the 2018 (Chemistry) Departmental Recognition Awards and Positron Award! Well done, Kat!

April 1, 2018
Our collaborative project with Jianmin Cui (WashU St Louis) and Xiaoqin Zou (Mizzou) on studies of the gating and pore-sensor coupling mechanisms of large current calcium-activated potassium (BK) channels has been funded by NIH/NHLBI through a 4-year R01 grant! (WashU News Release)

April 1, 2018
We welcome Dr. Azar Farjamnia to the lab as a Visiting Researcher!

Feb 21, 2018
Zhiguang presented his discovery of a hydrophobic gate in human BK channels at the Biophysical Society Annual Meeting in San Francisco.

Nov 1, 2017
Congratulations to Xiaorong for publishing her new Hybrid Resolution (HyRes) protein model, which provides semi-quantitative secondary structure propensities together with a qualitative description of long-range nonspecific interactions. This is a result of over two years meticulous and persistent work!

July 1, 2017
We welcome Justin and Katrina to lab as undergraduate researchers! Justin will work on molecular mechanism of chemotaxis (in collaboration with the Thompson lab), and Katrina will work on simulation of tumor suppressor p53.

Mar 1, 2017
Mahdieh Yazdani joined the lab as a graduate student. Mahdieh is originally from Iran and has been at UMass Amherst since 2014. We are glad that Madhieh finds computational biophysics exciting and appreciate her courage of re-inventing herself. Welcome!

Feb 24, 2017
After much ado, our new GPU cluster is finally powering up. It is housed in the beautiful Massachusetts Green High Performance Computing Center (MGHPCC) and has 32 4-GPU computing nodes.

Feb 1, 2017
We welcome Dr. Mara Chirocotto to the lab as a postdoctoral fellow. Mara is originally from Italy and received her PhD in Theoretical and Computational Biophysics from University Paris Diderot (Paris VII) in 2017.

Jan 17, 2017
Congratulations to Zhiguang and Alex for getting their paper on "The Levinthal Problem in Amyloid Aggregation: Sampling of a Flat Reaction Space" accepted by JPCB! This is a result of several years' hard work in collaboration with Jeremy Schmit's lab and our first paper on development of multi-scale algorithms for simulating the fibril growth mechanism and kinetics at atomistic details.

Jan 1, 2017
Enjoy and cherish every moment!

(IALS/LSL South)

(A fresh new day in a new year!)

(New England winter magic)

Jan 1, 2017
Our first day officially at University of Massachusetts Amherst! It has been quite a journay, through sunshine and snow.

(Snow storm around Cleveland)

(A beautiful day through Great Plains)

(UMass Central Library)

(UMass sunset)


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