Charbydotoxin - from Leiurus quinquestriatus scorpion
Neurotoxin a from the snake Naja nigricollis binds the acetylcholine receptor via a similar exposed b-sheet face
Convert charbydoxtoxin to a ìcurarimetric proteinî by changing 8 residues exposed on the face of the sheet.
Disulfide are key to this structure
This makes charybdotoxin an ideal platform from which to design new proteins
From: Biopolymers 47(1), 93-100, 1998
| Next slide | Back to first slide | View graphic version |