Goal: use stable protein motif as a scaffold onto which one builds an active site
Benefit: donít need to understand the protein folding problem
Problem: one must understand the active site and how to form it
From: ěProtein Design: On the Threshold of Functional Properties,î G. Tuchscherer, L. Scheibler, P. Dumy, M. Mutter, Biopolymers 47(1), 63-73, 1998
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