Using Light to Affect Biology

Chambers, J.J., Banghart, M.A., Trauner, D., Kramer, R.H. Light-induced depolarization of neurons using a modified Shaker K+ channel and a molecular photoswitch. J. Neurophysiol. 2006, 96, 2792-2796.

Kramer, R.H., Chambers, J.J., Trauner, D. Photochemical tools for remote-control of ion channels in excitable cells. Nature Chem. Bio. 2005, 1, 360-365.

Chambers, J.J., Gouda, H., Young, D.M., Kuntz, I.D., England, P.M. Photochemically Knocking Out Glutamate Receptors in Vivo. J. Am. Chem. Soc. 2004, 126(43), 13886-13887.

Using Chemistry to Understand Biology

McLean, T.H., Chambers, J.J., Parrish, J.C., Braden, M.R., Marona-Lewicka, D., Kurrasch-Orbaugh, D.M., Nichols, D.E. C-(4,5,6-Trimethoxyindan-1-yl)methanamine: A Mescaline Analogue Designed Using a Homology Model of the 5-HT2A Receptor. J. Med. Chem. 2006, 49, 4269-4274.

Chambers, J.J., Parrish, J.C., Jensen, N.H., Kurrasch-Orbaugh, D.M., Marona-Lewicka, D., Nichols, D.E. Synthesis and Pharmacological Characterization of a Series of Geometrically Constrained 5-HT2A/2C Receptor Ligands. J. Med. Chem. 2003, 46 (16), 3526-3535.

Chambers, J.J., Nichols, D.E. A Homology-Based Model of the Human 5-HT2A Receptor Derived From an In Silico Activated G-Protein Coupled Receptor. J. Comput. Aided Mol. Des. 2002, 16 (7), 511-520.

Chambers, J.J., Kurrasch-Orbaugh, D.M., Parker, M.A., Nichols, D.E. Translocation of the 5-Alkoxy Substituent of 2,5-Dialkoxyarylalkylamines to the 6-position: Effects on 5-HT2A/2C Receptor Affinity. Bioorg. Med. Chem. Lett. 2002, 12, 1997-1999.

Chambers, J.J., Kurrasch-Orbaugh, D.M., Parker, M.A., Nichols, D.E. Enantiospecific Synthesis and Pharmacological Evaluation of a Series of Super-Potent, Conformationally Restricted 5-HT2A/2C Receptor Agonists. J. Med. Chem. 2001, 44, 1003-1010.