March 20, 2019
Congratulations to Zhiguang to have his work on gating of TMEM16F
lipid scramblase accepted by Nature Commumications! This is a
collabrative efforts with Huanghe Yang's lab at Duke University.
Feb 02, 2019
The group celebrated the Chinese New Year together in Jianhan's
house and looked forward to a great Year of Pig!
Dec 19, 2018
The group celebrated a highly successful year 2018 and holidays
together! What a great year with so much to be thankful for and to
celebrate together! To name a few, Zhiguang & Mahdieh's discovery of
hydrophobic gating in BK channels, Azar's new faculty position in
the beautiful La Jolla, addition of two bright new graduate students
in Erik and Xiping, Xiping's new baby son, a newly minted PhD in
Xiaorong, and several new federal grants to support various research
projects, Jianhan surviving teaching Stat Mech and then Quantum
Mechanics both the first time ever ... We wish everyone the best and
look forward to another great year in 2019!
Dec 17, 2018
Our warmest congratulations to Xiaorong for a highly successful
defense of her PhD dissertation on "Multi-scale simulations of
Intrinsically Disordered Proteins"!
Dec 8, 2018
We are thrilled to add two new graduate students to the lab! Erik
Nordquist hails from Idaho. He has a BS from the College of Idaho,
majoring in Physics-Mathematics and Chemistry with minors in
Computer Science, History, and Philosophy!!. Xiping grew up in
Nanchang, China. He has a BS in Chemistry from
Nanchang University and a MS from Xiamen University, developing
density functional valence bond methods. We look forward to many
exciting contributions from Erik and Xiping in the coming years!
Nov 30, 2018
Congratulations to Mahdieh for winning another Best Poster Award, this
times at 8th Life Sciences Graduate Student Symposium of UMass!
Oct 20, 2018
Xiping and Mahdieh presented their works on GPU accelerated implicit
solvent and gating of BK channels in the 15th Annual North Eastern
Structure Symposium. Congratulations to Mahdieh for wining the Best
Aug 28, 2018
Congratulations to Xiaorong Liu for being selected as one of the six
speakers of the annual UMass Chemistry ResearchFest and winning the
prestigious William E. McEwen Graduate Fellowship!
Aug 24, 2018
We thank NIGMS for a generous Administrative Supplements for
Equipment of $140K for acquiring additional GPU computing nodes! It
will significantly increase our computing capacity to work on
several NIH supported projects!
Aug 22, 2018
Group members, Mahdieh, Xiaorong and Wayne, presented their exciting
works at the ACS national meeting in Boston. The crowds were
unusually large (not totally kidding)!
Aug 17, 2018
The group went to UMass Berkshire Dinning Common to enjoy the No. 1 Campus Food in the US and say farewell to Mara!
July 18, 2018
Congratulations to Zhiguang and Mahdieh for getting their paper on
hydrophobic gating of BK channels accepted
Communications! It is a lot of hard work and their
exciting discovery will have great impacts on those who are
interested in BK and other ion channels!
(UMass News Release)
July 10, 2018
We received a 4-year grant from National Science Foundation (NSF) to
develop efficient GPU-accelerated computational techniques and study
how proteins may exploit highly flexible structures for function!
(UMass News Release)
July 8, 2018
The group celebrated Kuohao's highly productive tenure in the Chen
lab at Jianhan's house! Kuohao will move to University of Kentucky
to be a Staff Scientist in the College of Pharmacy at the end of
July. It was a bittersweet moment and we all wish Kuohao and his
family the best!
July 1, 2018
The Journal of Molecular Biology Special Issue on "Intrinsically
Disordered Proteins: Structure, Function and Therapeutics",
co-edited by Jianhan Chen and Richard Kriwacki, is now available
online. The editorial overview can be found
June 15, 2018
Our collaborative project with Ned Debold (Kinesiology) and DV (Chemistry) on development
of a light-sensitive, high-energy molecule
to power muscle function during acute myocardial ischemia and fatigue has been funded
by a two-year Innovative Project Award by American Heart Association.
(UMass News Release)
April 11, 2018
Congratulations to Katrina for winning the 2018 (Chemistry)
Departmental Recognition Awards and Positron Award! Well done, Kat!
April 1, 2018
Our collaborative project with Jianmin Cui (WashU St Louis) and Xiaoqin Zou (Mizzou) on
studies of the gating and pore-sensor
coupling mechanisms of large current calcium-activated potassium
(BK) channels has been funded by NIH/NHLBI through a 4-year R01
grant! (WashU News Release)
April 1, 2018
We welcome Dr. Azar Farjamnia to the lab as a Visiting Researcher!
Feb 21, 2018
Zhiguang presented his discovery of a hydrophobic gate in human BK
channels at the Biophysical Society Annual Meeting in San Francisco.
Nov 1, 2017
Congratulations to Xiaorong for publishing her new
Resolution (HyRes) protein model, which provides semi-quantitative
secondary structure propensities together with a qualitative
description of long-range nonspecific interactions. This is a
result of over two years meticulous and persistent work!
July 1, 2017
We welcome Justin and Katrina to lab as undergraduate researchers!
Justin will work on molecular mechanism of chemotaxis (in
collaboration with the Thompson lab), and Katrina will work on
simulation of tumor suppressor p53.
Mar 1, 2017
Mahdieh Yazdani joined the lab as a graduate student. Mahdieh is
originally from Iran and has been at UMass Amherst since 2014. We
are glad that Madhieh finds computational biophysics exciting and
appreciate her courage of re-inventing herself. Welcome!
Feb 24, 2017
After much ado, our new GPU cluster is finally powering up. It is
housed in the beautiful Massachusetts Green High Performance
Computing Center (MGHPCC) and has 32 4-GPU computing nodes.
Feb 1, 2017
We welcome Dr. Mara Chirocotto to the lab as a postdoctoral
fellow. Mara is originally from Italy and received her PhD in
Theoretical and Computational Biophysics from University Paris
Diderot (Paris VII) in 2017.
Jan 17, 2017
Congratulations to Zhiguang and Alex for getting their paper on
Problem in Amyloid Aggregation: Sampling of a Flat Reaction
Space" accepted by JPCB! This is a result of several years'
hard work in collaboration with Jeremy Schmit's lab and our first
paper on development of multi-scale algorithms for simulating the
fibril growth mechanism and kinetics at atomistic details.
Jan 1, 2017
Enjoy and cherish every moment!
(A fresh new day in a new year!)
(New England winter magic)
Jan 1, 2017
Our first day officially at University of Massachusetts Amherst! It
has been quite a journay, through sunshine and snow.
(Snow storm around Cleveland)
(A beautiful day through Great Plains)
(UMass Central Library)